Apigenin is a bioflavonoid compound that can be found in a variety of plants and herbs. Chamomile tea is very abundant and plays an anxiolytic role when taken in high doses. At higher doses, it can be a sedative.A phytoflavonoid, it has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth by cell cycle arrest and induction of apoptosis appears to be associated with p53 induction. Pma-mediated tumor promotion was suppressed by inhibition of Chemicalbook protein kinase C and the resulting suppression of oncogene expression. Studies have also reported inhibition of topoisomerase ¢-catalyzed DNA rejoining and enhancement of gap junction intercellular communication.